Molecular Oncology

Author: Edward P. Gelmann
Publisher: Cambridge University Press
ISBN: 0521876621
Size: 42.26 MB
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ALK Protein X-ALK (a) Formation of ALK fusion proteins (b) Diagrams of ALK
fusion proteins ALK NPM-ALK 680 1 Protein X ALK ALK ALK ALK ALK ALK
RANBP2-ALK MYH9-ALK TPM4-ALK MSN-ALK CLTC-ALK ATIC-ALK TPM3-ALK
TFGXL-ALK ALK 1430 2201 1005 2197 792 803 784 784 1 1 1 1 1 1 1 1 ALK
EML4-ALK 1059 1 ALK KIF5B-ALK 1483 1 ALO17-ALK 1735 1 1169 1 ALK ALK
ALK CARS-ALK (c) Distribution of ALK fusion proteins in lymphoma Remaining
ALK fusion ...

Receptor Tyrosine Kinases Family And Subfamilies

Author: Deric L. Wheeler
Publisher: Springer
ISBN: 3319118889
Size: 43.86 MB
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NSCLC EML4-ALK KIFB-ALK TFG-ALK KLC -ALK PTPN-ALKHIP-ALK IMT TPM-
ALK TPM-ALK CLTC-ALK ATIC-ALK SECL-ALK RANBP-ALK PPFIBP-ALK CARS
-ALK Anaplastic Lymphoma Kinase ALK fusion proteins ALK overexpression
Ewing sarcoma Neuroblastoma (NB) Melanoma Breast cancer Non-Small-Cell-
Lung-Cancer Retinoblastoma Glioblastoma Astrocytoma Rhabdomyosarcoma
Ovarian cancer others ESCC TPM4-ALK RMC, RCC VCL-ALK TPM-ALK EML-
ALK ...

Molecular Genetic Testing In Surgical Pathology

Author: John D. Pfeifer
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781747486
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John D. Pfeifer. ALK FUSIONS IN INFLAMMATORY MYOFIBROBLASTIC
TUMOR Fusion Rearrangement Fusion Partner Cell Lymphomas References
RANBP2-ALK t(2;2)(p23;a13) Ran-binding protein 2 No 245 TPM3-ALK t(1:2)(
q25;p23) Tropomyosin 3 Yes 246 TPM4-ALK t(2;19)(p23;p13.1) Tropomyosin 4
Yes 246 CLTC-ALK t(2;17)(p23;q23) Clathrin Yes 247 CARS-ALK t(2;11)(p23;
p15) Cysteinyl-tRNA No 248,249 synthetase ATIC-ALK inv(2)(p23;q35) and
Amino terminus of Yes ...

Power Plant Water Chemistry

Author: Brad Buecker
Publisher: PennWell Books
ISBN: 9780878146192
Size: 24.49 MB
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... CAH<=275 THEN C=2 780 IF CAH>275 AND CAH<=345 THEN C=2.1 790 IF
CAH>345 AND CAH<=435 THEN C=2.2 800 IF CAH>435 AND CAH<=555
THEN C=2.3 810 IF CAH>555 AND CAH<=695 THEN C=2.4 820 IF CAH>695
AND CAH<=875 THEN C=2.5 830 IF CAH>875 AND CAH<=1000 THEN C=2.6
840 IF ALK>=10 AND ALK<=11 THEN D=l 850 IF ALK>=12 AND ALK<=13 THEN
D=l.l 860 IF ALK>=14 AND ALK<=17 THEN D=1.2 870 IF ALK>=18 AND ALK<=
22 THEN ...

The Lymphoid Neoplasms 3ed

Author: Ian Magrath
Publisher: CRC Press
ISBN: 1444113224
Size: 22.59 MB
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NPM-ALK; TPM3-ALK; ATIC-ALK; CLTC-ALK; TFG-ALK; MYH9-ALK; MSN-ALK;
ALO17-ALK CLTC-ALK (most cases); NPM-ALK (few cases)c TPM3-ALK; TPM4-
ALK; CLTC-ALK; RANBP2-ALK; CARS-ALK; SEC31L1-ALK bThe oncogenic role
of ALK protein in these tumors is not yet elucidated (no prognostic significance).
ALK, anaplastic lymphoma kinase; NPM, nucleophosmin; TPM3/4, non-muscular
tropomyosin; ATIC, amino-terminus of 5-aminoimidazole-4-carboxamide ...

Ioachim S Lymph Node Pathology

Author: Harry L. Ioachim
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781775960
Size: 65.74 MB
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No clear consensus exists regarding the criteria used for establishing the
diagnosis of ALK-ALCL, and many pathologists believe that this neoplasm is not
a distinct entity and is better classified as PTCL-U (6). Synonyms Ki-1+ large-cell
anaplastic lymphoma (Kiel); Ki-1 lymphoma; Diffuse large-cell or large-cell
immunoblastic (Working Formulation); malignant histiocytosis (subset).
Epidemiology and Pathogenesis Most epidemiologic studies do not separate
ALK+ and ALKneoplasms, ...

Science Of Synthesis Houben Weyl Methods Of Molecular Transformations Vol 33

Author:
Publisher: Georg Thieme Verlag
ISBN: 3131720913
Size: 49.64 MB
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fi Sulfides, alk-1-enyl, from cross coupling of 1-bromoalk-1-enes with
trialkylstannyl sulfides, palladium catalyzed 115 fi Sulfides, alk-1-enyl, from
decarboxylation of 2-(methylsulfanyl)propanoic acids 127, 128 fi Sulfides, alk-1-
enyl, from dehydrohalogenation of haloalkyl sulfides 121, 122 fi Sulfides, alk-1-
enyl, from deoxygenation of alk1-enyl sulfoxides 135, 136 fi Sulfides, alk-1-enyl,
from diastereoselective addition of 1-(methylsulfanyl)ethenethiolate to enones
113, 114 fi Sulfides, ...

Applying Pharmacogenomics In Therapeutics

Author: Xiaodong Feng
Publisher: CRC Press
ISBN: 1498782450
Size: 44.64 MB
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Anaplastic lymphoma kinase (ALK), also known as ALK tyrosine kinase receptor
or cluster of differentiation 246 (CD246), is encoded by the ALK gene located at
chromosome 2p23. The ALK tyrosine kinase receptor belongs to the insulin
receptor superfamily of receptor tyrosine kinases (RTKs). The deduced amino
acid sequences reveal that the ALK protein comprises an extracellular domain, a
putative transmembrane region, and an intracellular kinase domain. It plays an
important ...

Principles And Applications Of Aquatic Chemistry

Author: François M. M. Morel
Publisher: John Wiley & Sons
ISBN: 9780471548966
Size: 74.17 MB
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containing other weak acids and bases than CO2 and water. Focusing on the left-
hand side of the T0TH equation, we find for a simple carbonate system: Alk = -[H
+] + [OH] + [HCO3 ] + 2[CO^-] (15) and for a system that contains other natural
weak acids and bases: Alk = -[H+] + [OPT] + [HCO3o] + 2[CO2-] + [NH3] + [HS~] +
2[S2-] C-Alk N-Alk S-Alk + [HSiO3-] + 2[SiO23-] + [B(OH)4:]-[H3PO4] + [HPO2-] +
2[POr] Si- Alk B-Alk P-Alk (16) The species, H+, H2CO*, NH^, H2S, H2SiO3, B(
OH)3, ...