Discovering Design

Author: Richard Buchanan
Publisher: University of Chicago Press
ISBN: 9780226078151
Size: 65.34 MB
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But our curiosity went further than this: it also extended, in no small measure, to
established disciplines such as the philosophy of science and mathematical logic
. The mainspring of all our curiosity, or reading, and our theoretical work was our
determination to find a solid methodological basis for the work of design. This
was a highly ambitious undertaking, admittedly: we were seeking to force through
, in the field of design, a transformation equivalent to the process by which
chemistry ...

Author: Jared M. Diamond
ISBN: 9789747799149
Size: 75.68 MB
Format: PDF
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Author: Paulo Coelho
ISBN: 9789744719751
Size: 20.89 MB
Format: PDF, ePub, Docs
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En andalusisk fårehyrde, Santiago, drømmer om en skat og rejser til pyramiderne for at finde den. Ved at følge sit hjerte og søge sin skæbne opnår han rigdom og lykke

The God Hypothesis

Author: Michael Anthony Corey
Publisher: Rowman & Littlefield
ISBN: 9780742558892
Size: 37.16 MB
Format: PDF, Kindle
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Discovering Design in Our Just Right Goldilocks Universe Michael Anthony
Corey. CHAPTER SEVEN Science and the Design Argument If we can accept
that the day-to-day actions of living organisms are direct consequences of the
molecules that make them up, why should it be any more difficult to see that
similar principles are behind the evolution of those organisms? If the Creator
uses physics and chemistry to run the universe of life, why wouldn't He have used
physics and ...

Discovering Chemistry With Natural Bond Orbitals

Author: Frank Weinhold
Publisher: John Wiley & Sons
ISBN: 1118229193
Size: 37.51 MB
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... distinct forward and reverse NBO delocalizations impose complementary
stereoelectronic constraints on the transition state. In summary, we can see how
the freedom to apply either reactant-like or product-like NBO analysis offers
valuable insights into the ambivalent structural and electronic demands of
transition-state species, suggesting new possibilities for rational catalyst design.
More generally, the NRT method allows easy extension to continuous description
of electronic shifts ...

Information Science For Materials Discovery And Design

Author: Turab Lookman
Publisher: Springer
ISBN: 331923871X
Size: 30.59 MB
Format: PDF, ePub
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Discovering. Electronic. Signatures. for. Phase. Stability. of. Intermetallics. via.
Machine. Learning. Scott R. Broderick and Krishna Rajan Abstract In this paper,
we identify the signatures of the density of states (DOS) spectra which control the
bulk ... Information Science for Materials Discovery and Design, Springer Series
in Materials Science 225, DOI 10.1007/978-3-319-23871-5_12 223 where the
input is the chemistry and structure, and the 12 Discovering Electronic Signatures
for ...

Peptide Chemistry And Drug Design

Author: Ben M. Dunn
Publisher: John Wiley & Sons
ISBN: 1118996410
Size: 55.87 MB
Format: PDF, Mobi
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This book focuses on peptides as drugs, a growing area of pharmaceutical research and development.

Discovering Partial Least Squares With Jmp

Author: Ian Cox
Publisher: SAS Institute
ISBN: 1612908292
Size: 55.40 MB
Format: PDF
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Multivariate Analysis; Proceedings. New York: Academic Press, 391–420. Wold,
H. (1980). “Soft Modelling: Intermediate between Traditional Model Building and
Data Analysis,” Mathematical Statistics (Banach Center Publications, Warsaw), 6,
333–346. Wold, S. (1995), “PLS for Multivariate Linear Modeling,” in
Chemometric Methods in Molecular Design. Methods and Principles in Medicinal
Chemistry, van de Waterbeemd, H. (ed.), New York: VCH. [SAS Library Note: The
second part ...

Discovering And Developing Molecules With Optimal Drug Like Properties

Author: Allen C Templeton
Publisher: Springer
ISBN: 1493913999
Size: 28.79 MB
Format: PDF, ePub, Docs
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Chapter. 5. The. Importance. of. Molecular. Design. Principles. in. Delivering.
High. Quality. Pharmaceutical. Candidates. Thomas E. Prisinzano ... Among
these disciplines are molecular biology, behavioral pharmacology, and medicinal
chemistry. Historically ... Discovering and Developing Molecules with Optimal
Drug-Like Properties, AAPS Advances in the Pharmaceutical Sciences Series 15,
DOI 10.1007/978-1-4939-1399-2_5 177 a[potency]+b[efficacy]+ c[selectivity]+d[
toxicity] + ...

The Practice Of Medicinal Chemistry

Author: Camille Georges Wermuth
Publisher: Academic Press
ISBN: 9780080568775
Size: 60.47 MB
Format: PDF, Mobi
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Jahnke, W., Flörsheimer, A., Blommers, M. J. J., Paris, C. G., Heim, J., Nalin, C. M.
, Perez, L. B. Second-site NMR screening and linker design. Curr. Top. Med.
Chem. 2003, 3, 69–80 ... Nienaber, V. L., Richardson, P. L., Koighofer, V., Bouska
, J. J., Giranda, V. L., Greer, J. Discovering novel ligands for macromolecules
using Xray crystallographic screening. Nat. Biotechnol. 2000, 18 ... Med. Chem.
2005, 5, 421–439. Michne, W. Hit-to-lead chemistry: a key element in new lead