P53 In The Clinics

Author: Pierre Hainaut
Publisher: Springer Science & Business Media
ISBN: 1461436761
Size: 40.25 MB
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p53: Guardian. of. the. Genome. Cancer is usually associated with deregulated
cell cycle progression and impaired apoptosis induction due to the activation of
proto-oncogenes and/or inactivation of tumor suppressor genes (Hanahan and
Weinberg 2000). Mutation of the TP53 tumor suppressor gene, the “guardian of
the genome,” is found in ~50 % of human cancers. The p53 molecule plays a
critical role in tumor suppression mainly by trigger- ing growth arrest, apoptosis,
and ...

Lung Cancer An Issue Of Clinics In Chest Medicine

Author: Lynn T. Tanoue
Publisher: Elsevier Health Sciences
ISBN: 1455709719
Size: 42.52 MB
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5).159 p53 inactivating mutations are the most common alterations in lung cancer
, whereby 17p13 frequently demonstrates hemizygous deletion and mutational
inactivation in the remaining allele.160–162 Some point mutations in TP53
confer a gain-of-function phenotype leading to increased aggressiveness of lung
cancer.163 Due to the prevalence of p53 inactivating mutations in human
cancers, largescale efforts have been focused on therapeutic strategies to restore
normal p53 ...

Photodermatology An Issue Of Dermatologic Clinics

Author: Henry Lim
Publisher: Elsevier Health Sciences
ISBN: 0323311806
Size: 58.62 MB
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This is accomplished through p53, a tumor suppressor gene that plays a central
role in cell repair, apoptosis, and cell-cycle arrest to Fig. 1. Mechanisms of UV-
induced photocarcinogenesis. allow time for repairs. The levels of p53 are
increased in normal keratinocytes after UVR exposure.6 If the p53 gene is
mutated, the cell may not be able to repair itself, leading to permanent damage.
The cell may also become resistant to apoptosis.8 P53 mutations have been
demonstrated in ...

Cytopathology An Issue Of Surgical Pathology Clinics

Author: Tarik El Sheikh
Publisher: Elsevier Health Sciences
ISBN: 0323261337
Size: 14.53 MB
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Reactive ductal cells are negative for p53, maspin, S100P, and IMP-3 and
positive for Dpc4 and PDA is positive for p53, maspin, S100P, and IMP-3;
negative for Dpc4 and pVHL; and negative or PDA shows somatic mutations of K-
RAS, p16/CDKN2A, p53, and DPC4/SMAD4, which are not seen Duodenal
epithelium forms sheets of columnar cells with interspersed goblet cells and has
an asso Duodenal epithelium is positive for CDX2 and Dpc4 but negative for p53
immunostain.

Molecular Oncology An Issue Of Surgical Pathology Clinics

Author: Jennifer Hunt
Publisher: Elsevier Health Sciences
ISBN: 1455750530
Size: 27.47 MB
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Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: a
marker for disease progression. J Natl Cancer Inst 1993;85:53–9. Sarkis AS,
Dalbagni G, Cordon-Cardo C, et al. Association of P53 nuclear overexpression
and tumor progression in carcinoma in situ of the bladder. J Urol 1994;152:388–
92. Sarkis AS, Bajorin DF, Reuter VE, et al. Prognostic value of p53 nuclear
overexpression in patients with invasive bladder cancer treated with neoadjuvant
MVAC.

Pediatric Otolaryngology Challenges In Multi System Disease An Issue Of Otolaryngologic Clinics

Author: Austin Rose
Publisher: Elsevier Health Sciences
ISBN: 1455744247
Size: 13.24 MB
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Molecular transformation of recurrent respiratory papillomatosis: viral typing and
p53 overexpression. AnnOtol Rhinol Laryngol.2003;112(4):298-302. 22. C.S.
Miller,B.M.Johnstone. Humanpapillomavirusasarisk factor for oral squamous cell
carcinoma: a meta-analysis, 1982-1997. Oral Surg Oral Med Oral Pathol Oral
Radiol Endod. 2001;91(6):622-635. 23. E.M. Smith,S.S.Pignatari, S.D.Gray,etal.
Human papillomavirus infection in papillomas andnondiseased
respiratorysitesofpatients ...

Breast Cancer An Issue Of Surgical Oncology Clinics Of North America

Author: Lisa Newman
Publisher: Elsevier Health Sciences
ISBN: 032331192X
Size: 72.38 MB
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BRCA2 cancers are also usually HER2-negative, but tend to be ER/PR-positive.
59 P53/Li-Fraumeni syndrome P53 is another high-penetrance gene with a
proven link to breast cancer. Mutations in P53 are associated with Li-Fraumeni
syndrome (LFS), which carries an increased risk of breast cancer as well as
leukemia and malignancies of the lung and brain.60 Women with LFS have a 50
% risk of breast cancer by age 60.61 LFS and P53-associated malignancies may
account for ...

Pediatric Hematology An Issue Of Pediatric Clinics

Author: Catherine S. Manno
Publisher: Elsevier Health Sciences
ISBN: 0323261191
Size: 50.90 MB
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As noted earlier, increased understanding of DBA came through amelioration of
its phenotype in a p53 knockout background in both the mouse and the zebrafish,
leading to a lower rate of apoptosis and suggesting that the imbalance of
ribosome synthesis or inefficiency of protein translation leads to cell stress. In
addition, RPS26 has been shown through an RPL11-mediated pathway to
stabilize p53 via interaction in an inhibitory fashion with MDM2, which is the E3
ubiquitin ligase for ...

Advances In Veterinary Oncology An Issue Of Veterinary Clinics Of North America Small Animal Practice

Author: Annette N. Smith
Publisher: Elsevier Health Sciences
ISBN: 0323323529
Size: 12.77 MB
Format: PDF, Mobi
View: 3597
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... of MMP and leukotrienes Bupleurum (Radix Bupleuri) Saikosaponins
Increased Fas/Fas ligand apoptotic system, inhibition of COX-2 and reactive
oxygen species (ROS)-mediated apoptosis Carthamus Safflower polysaccharide
Apoptosis, increased cytotoxic NK cells Coptis Berberine Bax/Bcl-2 apoptosis,
activation of caspase and PARP Curcumin (Curcuma longa) Inhibition of COX-2,
cyclin D1, and MMPs; inhibition of NF-kB, STAT, and TNF-a signaling; p53
expression regulation; ...

Molecular Pathology An Issue Of Clinics In Laboratory Medicine

Author: Martin H. Bluth
Publisher: Elsevier Health Sciences
ISBN: 0323261051
Size: 22.74 MB
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Abnormally produced C-MYC activates a protective pathway through the
induction of p53-dependent cell death pathway, among others, such as p14ARF
and BCL-2 like protein11 (BIM), which forces such cells to undergo apoptosis.
p53 plays an important role in MYC-induced apoptosis, and around 30% of
endemic BL harbor a p53 mutation. BL is characterized by having C-MYC
translocation with the JH region of immunoglobulin heavy chain (14q32) (80%)
and less frequently with ...